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  Current Standards of Care & Advances in Immunotherapy

A Roundtable Discussion:


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Underlying the discussion were two seminal publications:  Allergen Immunotherapy: A Practice Parameter Third Update1 and Sub-Lingual Immunotherapy:  World Allergy Organization Position Paper 2009.2 Other research cited by the roundtable participants during the discussion are footnoted and included below. 

  1. Cox L, Nelson H, Lockey R, et al. Allergen immunotherapy: a practice parameter, third update. J  Allergy Clin Immunol. 2011;127(1):S1-S55.
  2. Bousquet J, Cox LS, Durham SR, et al.  Sub-lingual immunotherapy: World Allergy Organization Position Paper.  Allergy 2009;64(91):1-59.
  3. Braganza SC, Acworth JP, McKinnon DR, Peake JE, Brown AF.  Paediatric emergency department anaphylaxis: different patterns from adults. Arch Dis Child. 2006;91(2):159–63.
  4. Pajno GB, Barberio G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy. 2001;31(9):1392-7.
  5. Purello-D’Ambrosio F, Gangemi S, Merendino RA, et al.  Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. Å retrospective study. Clin Exp Allergy. 2001;31(8):1295-302.
  6. Muller U, Hari Y, Berchtold E. Premedication with antihistamines may enhance efficacy of specific-allergen immunotherapy.  J Allergy Clin Immunol. 2001;107(1):81-6.
  7. Majak P, Rychlik B, Pułaski L, et al. Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma. J Allergy Clin Immunol. 2010;125(6):1220-7.
  8. Nielsen L, Johnsen CR, Mosbech H, Poulsen LK, Malling HJ. Antihistamine premedication in specific cluster immunotherapy: a double-blind, placebo-controlled study. J Allergy Clin Immunol. 1996;97(6):1207-13
  9. Ohashi Y, Nakai Y, Murata K.  Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis. Ann Allergy Asthma Immunol. 2006;96:600-5
  10. Bernstein DI, Epstein T, Murphy-Berendts K, Liss GM.  Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study. Ann Allergy Asthma Immunol. 2010;104(6):530-5.
  11. Roy SR, Sigmon JR, Olivier J, et al.  Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy.  Ann Allergy Asthma Immunol. 2007;99(1):82-6.
  12. Tankersley MS, Butler KK, Butler WK, Goetz DW. Local reactions during allergen immunotherapy do not require dose adjustment. J Allergy Clin Immunol. 2000;106(5):840-3.
  13. Nelson BL, Dupont LA, Reid MJ. Prospective survey of local and systemic reactions to immunotherapy with pollen extracts. Ann Allergy. 1986;56(4):331-4.
  14. Nelson HS, Nolte H, Creticos P, et al. Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults. J Allergy Clin Immunol. 2011;127(1):72-80, 80.e1-2.
  15. Blaiss M, Maloney J, Nolte H, et al. Efficacy and safety of timothy grass immunotherapy tablets in North American children and adolescents. J Allergy Clin Immunol. 2011;127(1):64-71.
  16. Nasser S, Vestenbaek U, Beriot-Mathiot A, Poulsen PB. Cost-effectiveness of specific immunotherapy with Grazax in allergic rhinitis co-existing with asthma. Allergy. 2008;63(12):1624-29.
  17. Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study.  J Allergy Clin Immunol. 2010;126(5):969-75.
  18. Ciprandi G, Cadario G, Di Gioacchino GM, et al.  Sublingual immunotherapy in children with allergic polysensitization.  Allergy Asthma Proc.  2010;31(3):227-31.
  19. Senna G, Lombardi C, Canonica GW, Passalacqua G. How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers’ viewpoint. J Allergy Clin Immunol. 2010;126(3):668-9
  20. Vita D, Caminiti L, Ruggeri P, Pajno GB. Sublingual immunotherapy: adherence based on timing and monitoring control visits.  Allergy. 2010;65(5):668-9.
  21. Ott H, Sieber J, Brehler R, et al. Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: the ECRIT study. Allergy. 2009;64(1):179-86.
  22. Cox LS, Larenas-Linnemann DE, Nolte H, et al.  Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol. 2006;117(5):1021-35.
  23. Novembre E, Galli E, Landi F, et al.  Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2004;114(4):851-7.
  24. Alvarez-Cuesta E, Bousquet J, Canonica GW, et al.  Standards for practical allergen-specific immunotherapy.  Allergy. 2006;61(82):1-20.
  25. Agostinis F, Forti S, Di Berardino F. Grass transcutaneous immunotherapy in children with seasonal rhinoconjunctivitis. Allergy. 2010;65(3):410-11.
  26. Senti G, Graf N, Haug S, et al. Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy. J Allergy Clin Immunol. 2009;124(5):997-1002.
  27. Immunotherapy International Conference, October 2010, Taormina, Sicily.
  28. Senti G, Prinz Vavricka BM, Erdmann I, et al. Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial.  Proc Nat Acad Sci USA. 2008;105(46):17908-12.
  29. Hankin CS, Cox LS, Wang Z, Bronstone A.  Does allergen-specific immunotherapy provide cost benefits for children and adults with allergic rhinitis? Results from large-scale retrospective analyses jointly funded by AAAAI and ACAAI.  J Allergy Clin Immunol.  2011;127:AB73.  Abstract 274.
  30. Wang Z, Hankin CS, Cox L, Bronstone A.  Allergen immunotherapy significantly reduces healthcare costs among U.S. Adults with allergic rhinitis: a retrospective matched cohort study jointly funded by the AAAAI and ACAAI.  J Allergy Clin Immunol.  2011;127:AB159.  Abstract 569.


Perspectives Article published in the November 2011 issue of Annals of Allergy, Asthma and Immunology.

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