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Q: 
My friend has severe contact dermatitis, including intermittent fevers up to 103, from overexposure to epoxy while working in a boatyard. Could this be an allergic reaction? He has been treated by a dermatologist with steroid injections and mild antihistamines, but he is not getting better. His symptoms have been severe for several weeks. Would this be better treated by an allergist?
A: 
Epoxy resin can cause more than one type of allergic reaction, but a specific patient usually has only one. It would seem that your friend may be having two different types of unrelated allergic reactions. The following is a summary of some medical facts about contact dermatitis and hypersensitivity pneumonitis, which have both been reported in association with epoxy resin. Your friend should completely avoid all exposure to epoxy resin, and should schedule a consultation with an allergist to better diagnose and evaluate his symptoms. A material safety data sheet may help your friend identify potential sources of exposure.

Contact dermatitis is the most common allergic reaction to epoxy resin and tends to occur when there is skin contact with uncured epoxy resin. While bisphenol A is the main allergen, other components (e.g., epichlorohydrin, diglycidyl ether) may also cause skin irritation. After the epoxy resin hardens, curing can take up to 2 weeks. However, patients who are very sensitive can even react to “cured” products containing epoxy resin. Nitrile rubber or nitrile butyl gloves, in addition to goggles and protective clothing are recommended for avoidance. Epoxy resin is widely used for sporting goods, dental work, and vehicle parts. For patients with dermatitis related to exposure, corticosteroids and emollients are frequently used for treatment. Unfortunately, in sensitive patients, recurrence of dermatitis occurs with re-exposure to epoxy resin.

Fever is not typically seen with contact dermatitis, but can be one of the symptoms of hypersensitivity pneumonitis or inhalation fever. In both hypersensitivity pneumonitis and inhalation fever, inhaling epoxy fumes or dust results in symptoms within a few hours. Both of these diseases can start with fever, chills, malaise, nausea, headaches and myalgias (muscle pains). While inhalation fever is not associated with lung symptoms, hypersensitivity pneumonitis is associated with cough, chest tightness, and shortness of breath. Hypersensitivity pneumonitis can develop into a very serious chronic lung disease. when hypersensitivity pneumonitis is present, the allergist is likely to find abnormalities on physical exam, chest x-ray, labs, and pulmonary function studies. If either of these two conditions are diagnosed, the patient should strictly avoid exposure to epoxy resin.