Food Protein Induced Enterocolitis Syndrome (FPIES) is a type of non-IgE mediated food allergy that can present with severe vomiting, diarrhea and dehydration. Like other food allergies, FPIES reactions are triggered by eating a particular food. The most common triggers include cow milk, soy and grains (rice, barley, oats). The most severe forms of FPIES can lead to drop in energy, change in body temperature and low blood pressure leading to hospitalization. FPIES is frequently misdiagnosed early on as a potential severe blood infection or repeated infections of a gastrointestinal virus. Unlike most food allergies there is no blood or skin testing available for diagnosis. The primary treatment is strict avoidance of the triggering food. Most children outgrow FPIES by age 3 or 4.
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